Volume 17, Issue 3 (Fall 2013)
Physiol Pharmacol 2013, 17(3): 315-327 |
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Ghaffari S, Hatami Nemati H, Dehghan G. Protective Effect of Short-term Administration of Ethanolic Saffron Extract on improvement of Cognitive Deficits and Decrement of Lipid Peroxidation induced by Ethidium Bromide in Experimental Models of MS. Physiol Pharmacol 2013; 17 (3) :315-327
URL: http://ppj.phypha.ir/article-1-930-en.html
URL: http://ppj.phypha.ir/article-1-930-en.html
Abstract: (13717 Views)
Introduction: Cognitive dysfunction is recognized as a significant feature of multiple sclerosis (MS). Oxidative
stress plays an important role in the pathogenesis of MS. Toxic demyelination by ethidium bromide (EB) is one of the
common methods for induction of MS, which leads to neuronal death by production of free radicals and enhancement of
oxidative stress burden. According to previous pharmacological studies, saffron extract acts as a free radical scavenger.
Accordingly, in the present study the effect of short-term microinjection of saffron extract on the process of spatial
memory and lipid peroxidation in the hippocampus was assessed in an experimental model of MS.
Methods: One week after MS induction by EB (0.01 %), animals of the experimental group were treated by saffron
extract (5 and 10 μg/rat) for 3 consecutive days. Following the treatment period, Morris Water Maze test was carried
out and hippocampi of both sides were dissected and used for measurement of a lipid peroxidation marker (MDA) in the
end.
Results: Based on the results of the present study, short-term treatment by saffron extract significantly ameliorated
spatial memory in experimental models of MS (P<0.05). MDA in the saffron treated group showed a significant
reduction compared to the control MS animals (P<0.01).
Conclusion: It seems that treatment with saffron extract is able to prevent memory and learning reduction, through
inhibition of lipid peroxidation in an experimental model of MS. However, evaluation of beneficial effects of saffron on
the spatial memory and its role in preventing or treating cognitive deficits in MS patients, requires much more extensive
molecular studies.
Type of Manuscript: Experimental research article |
Subject:
Neurophysiology/Pharmacology
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