Volume 19, Issue 3 (September 2015)                   Physiol Pharmacol 2015, 19(3): 146-157 | Back to browse issues page

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Ashabi G, Khodagholi F, Zare-shahamati S, Ghadernezhad N, Maleki M, Khalaj L. A comprehensive approach to investigate the contradictory effects of metformin therapy in cerebral ischemic injury. Physiol Pharmacol. 2015; 19 (3) :146-157
URL: http://ppj.phypha.ir/article-1-1124-en.html
Abstract:   (4051 Views)

Ischemic brain injury involves a complex sequence of excitetoxic and oxidative events. Metformin is proposed as one of the potential candidates for returning the body to its basic homeostasis in ischemic situations. Metformin can either protect or damage cells by activating AMP-activated protein kinase (AMPK) and its downstream factors so, it has a dual role in the cerebral ischemia context, but more investigations are needed to define its exact underlying mechanism. Herein, we classify the controversial results of metformin therapy in the experimental models of brain ischemia central and peripheral injection of metformin, chronic and acute treatment, pre- and post-treatment with metformin, tissue-specific role of metformin, dose-specific effect of metformin, age-dependent aspects of metformin therapy. Categorizing different types of cerebral ischemia is important in investigating the dual role of metformin. Due to the variations in metformin therapy, it can be used for chronic treatment, but the patients must be informed about its harmful effects. Although the mechanisms in which AMPK protects/degenerates neurons against ischemic stress situation are still unknown.

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Types of Manuscript: Review article | Subject: Neurodegeneretive diseases