Volume 18, Issue 4 (Winter 2015)
Physiol Pharmacol 2015, 18(4): 383-396 |
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Sarahian N, Sahraei H, Zardooz H, Ali-Beik H, Sadeghi B, Javadifar T, et al . Comparison of effect of intraperitoneal vs. intra-accumbal injection of memantine on response to acute stress in female NMRI mice. Physiol Pharmacol 2015; 18 (4) :383-396
URL: http://ppj.phypha.ir/article-1-1027-en.html
URL: http://ppj.phypha.ir/article-1-1027-en.html
Nahid Sarahian 
, Hedayat Sahraei , Homeira Zardooz , Hengameh Ali-Beik , Bahareh Sadeghi , Taherehsadat Javadifar , Gholamreza Herfehdoost , Badri Zarrin Ehteram , Zahra Ghanbari , Fatemehsadat Hoseini-Namvar
, Hedayat Sahraei , Homeira Zardooz , Hengameh Ali-Beik , Bahareh Sadeghi , Taherehsadat Javadifar , Gholamreza Herfehdoost , Badri Zarrin Ehteram , Zahra Ghanbari , Fatemehsadat Hoseini-Namvar
Abstract: (6842 Views)
Introduction: In this study, the effect of memantine administration into the nucleus accumbens on the metabolic
changes induced by acute stress in female mice was evaluated.
Methods: Intra-accumbens unilateral or bilateral canulation was performed. One week after recovery, a group of
animals were given memantine (1, 0.5, and 0.1 μg/mouse) five min before stress induction intra-accumbally, and the
other group received it (1, 0.5 and 0.1 mg/kg) 30 min before stress intraperitoneally. Food and water intake, weight of
fecal material, and the delay time before eating were measured as metabolic parameters after stress induction.
Results: Acute stress reduced water and food intake, fecal matter, and the delay time before eating. Intraperitoneal
memantine injections augmented the stress effect on water intake, but inhibited its effect on food intake at dose of 0.1
mg/kg and had no impact on defecation. The drug induced anorexia especially at dose of 1 mg/kg. On the other hand,
intra-accumbens memantine injections reduced water intake when the drug was injected in the left side. Moreover,
memantine injections inhibited or enhanced the effects of stress on water intake, food intake and defecation in a doseand
location-dependent manner, and also increased the delay time before eating.
Conclusion: Memantine inhibits or enhances the effects of acute stress dose-dependently. In addition, it seems that
there is asymmetry in nucleus accumbens response.
Type of Manuscript: Experimental research article |
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