Volume 22, Issue 1 (Winter 2018)                   Physiol Pharmacol 2018, 22(1): 1-10 | Back to browse issues page

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Sadat-Shirazi M, Ashabi G, Babhadiashar N, Bahrami Hessari M, Vousooghi N, Zarrindast M. Executive functions are related to serum testosterone and basal metabolism rate fluctuation but not lymphocyte dopamine receptor expression in the young healthy participants. Physiol Pharmacol 2018; 22 (1) :1-10
URL: http://ppj.phypha.ir/article-1-1310-en.html
Executive functions are related to serum testosterone and basal metabolism rate fluctuation but not lymphocyte dopamine receptor expression in the young healthy participants
Mitra-Sadat Sadat-Shirazi , Ghorbangol Ashabi , Nima Babhadiashar , Mohammadreza Bahrami Hessari , Nasim Vousooghi , Mohammad-Reza Zarrindast
Abstract:   (3550 Views)
Introduction: Herein, we evaluated linkages between EFs performances and dopamine receptor (DR)  mRNA and testosterone level in the young Iranian male people. Methods: All 140 participants were normalized using depression, anxiety and stress scale questionnaire. Remained 108 volunteers were tested against drug abuse and then volunteers were distinguished by Wisconsin Card Sorting Test (WSCT). According to WCST, participants were divided into two low and high EFs performance. Afterward, anthropometric factors, body mass index (BMI) and serum testosterone level were measured in low and high EFs groups. Blood samples were collected, and biochemical and anthropometric data were evaluated; serum testosterone and DR mRNA expression were assessed in participants. Results: Data showed there are no differences between two groups in Na+, K+, glucose, urea, creatinine, SGPT, SGOT and other biochemical serum agents (P>0.05) but BMI was increased in low EFs compared with high EFs (P=0.000). Interestingly, there is no difference in DR expression between two groups (P>0.05). Conclusion: Our data presented that fluctuation of EFs performances in healthy adult male cases might depend on BMI and serum testosterone; while dopamine receptors in the blood lymphocytes had no substantial role in the EFs. High serum testosterone reduced EFs in the young adults.
Keywords: Executive function, Dopamine receptor, Testosterone, Young people, Blood lymphocytes, Body mass index
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Type of Manuscript: Experimental research article | Subject: Neurophysiology/Pharmacology
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