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Abstract:   (18 Views)
Diffusible molecule of nitric oxide is an important regulator involved in functional adaptation in all tissues to exercise, as shown in recent studies. The aim of this short-term study was to evaluate the hypothesis that the important factor of higher performance of females during exhaustive exercise can be the interaction between physiological effect of nitric oxide and oxidant/antioxidant response. Males and females of trained mice were divided into three groups: basal, fasting and exercise. Parameters of oxidant/antioxidant state, including nitric oxide, were measured in blood and tissues. Females showed greater basal levels of nitric oxide, total antioxidant status and glutathione peroxidase in most tissues evaluated. Compared to fasting levels the net effects of prolonged exercise included lipoperoxidation in liver, brain and kidney, and nitrosative stress in liver, muscle and heart only in males. The decrement of glutathione without significant changes in its grade of oxidation was observed in liver, intestine, and adipose tissue only in females, confirmed possible redistribution of reduced glutathione during prolonged exercise. The results support the initial hypothesis that expressed in higher basal levels of nitric oxide and antioxidant defense in most tissues of females and greater capacity to counteract oxidative stress during prolonged exercise, compared to males in this animal model.
Types of Manuscript: Original Research | Subject: Others