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Abstract:   (81 Views)
The aim of this study was to evaluate gender differences in the oxidant/antioxidant response in different tissues during the stress of prolonged swimming with the additional oxidative challenge of HBOP beforehand. Trained mice of both genders treated by hyperbaric oxygen were divided into three groups, including basal, fasting and prolonged exercise. Parameters of oxidant/antioxidant state, including nitric oxide, were measured in blood and different tissues. Gender differences in the effects of HBOP were analyzed in the basal levels, fasting and in the net response to prolonged exercise. Compared to males, females of the non-treated group (Part 1) showed a greater basal level of NO and antioxidant defense in most tissues evaluated, and did not show an increase in lipid peroxidation during prolonged exercise. HBOP diminished the elevated basal levels of all measured parameters in females, including oxidative stress indicators, and glutathione. Therefore, females after HBOP started prolonged exercise with a lower basal level of oxidant/antioxidant state in most tissues than those of the non-treated group that coincided to the decrease in exhaustive exercise. During exercise, females after HBOP showed a strong net response in the liver and stability in muscle tissue, while in males the contrary response was found. In all tissues, there were gender differences in the response to prolonged exercise.  The results support the idea that the interaction between the antioxidant defense and the levels of NO, expressed in basal levels and the response to prolonged exercise, were of utmost importance in determining the greater performance of females.
Types of Manuscript: Original Research | Subject: Others