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Abstract:   (104 Views)
Introduction: In this study, we assessed the effects of chronic scheduled dietary on ghrelin plasma levels and food intake in adult male rats.
Methods: Forty male Wistar rats (180-200­gr) were distributed into four groups (n=10), freely fed rats (control) and three scheduled-fed groups with different caloric intakes; high fat, standard and restricted diet. Then, plasma ghrelin levels and food intake were measured on days 0, 7 and 14.
Results: Plasma ghrelin levels were significantly different among all groups over the time, the scheduled-standard feeding rats having the lowest ghrelin levels on day 7 (p<0.05), and the restricted feeding rat having the highest ghrelin levels on day 14 (p<0.05). It was noteworthy that fasted ghrelin value in control was as much as those of scheduled groups in the end of experiment exception restricted diet group. Control rats consumed stable food over the time, while scheduled groups showed time and caloric-dependency of food intake. Schedule-standard diet group consumed high level of food as well as restricted group on feeding time (p<0.05). Schedule-high fat diet group displayed a significantly time dependent reduction in food intake.
Conclusion: A component of ghrelin secretion can be entrained or learned for time feeding as well as long last-fasting and more is affected by quantitative and qualitative of caloric intake. Elevated ghrelin levels in restricted model are subjective both by low energy levels and learning. Also, amount of caloric intake can be controlled by learning; we observed a reduction in meal size in scheduled–high fat diet.
Types of Manuscript: Original Research | Subject: Gastrointestinal system