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Abstract:   (152 Views)

Introduction: Consumption of MDMA (3,4-methylenedioxymethamphetamine, ecstasy), a derivative of amphetamine, can results in various undesirable side effects including hematological and serological parameters. This study is intended to examine the effects of Curcumin along with MDMA in the early and late phase of consumption on hematological parameters and serum immunoglobin (IgM, IgG, IgA) levels.

Methods: We used 56 male rats that are divided into 7 Groups: Group1 (Control), Group2 (MDMA+vehicle1), Group3 (curcumin), Group4 (curcumin, MDMA+early curcumin), Group5 (MDMA+vehicle2), Group6 (MDMA+late curcumin), Group7 (MDMA+early&late curcumin ). The groups were received MDMA (20 mg/kg) orally and curcumin (20µM/kg) intra-peritoneally for 2 and 4 weeks (n=8). After 24 hr of final dose, rats were anesthetized and blood samples were collected and used for determination of hematological parameters and immunoglobin (Ig) M, IgG, IgA levels with using a Coulter Automated Cell Counter and ELISA kit.

Results: Our data indicated that either MDMA alone or in combination with curcumin in both early and late phase decreased lymphocytes, platelet, total leukocyte count and  RBC, MCHC, RDW, immunoglobin levels, as well as Hb content in comparison with the control group. In contrast, the amount of neutrophils, eosinophils, monocytes, mean cell volume (MCV), and HCT increased. Furthermore, we observed blood parasites of red blood cells in the MDMA groups with curcumin.

Conclusion: In conclusion, MDMA alone and in combination of curcumin altered the hematological parameters. Furthermore, their combination therapy induces toxic effects on hematological parameters and serum immunoglobin levels. This is a serious consequence for recreational drug users.

     
Types of Manuscript: Original Research | Subject: Pharmacology