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Abstract:   (119 Views)
Introduction: Antioxidant and anti-inflammatory features of Centella asiatica hydroalcoholic extract is documented in various diseases. This study aimed to investigate the effect of Centella asiatica hydroalcoholic extract on gentamicin nephrotoxicity (GM). Methods: In this study, 28 male Wistar rats were studied in 4 groups (namely control, sham, GM + normal saline (NS), and GM + Centella asiatica extract). In order to have nephrotoxicity induction, gentamicin (100 mg/kg) was injected as i.p. injection during seven days, and then the samples had Centella asiatica (100 mg/kg) i.p. injection for 7 days. Finally, the blood samples were collected from their heart in order to measure the creatinine (Crp) and plasma Urea Nitrogen (BUNp) levels. Oxidative stress indices were also measured through assessing the malondialdehyde (MDA) and ferric reduction antioxidant power (FRAP) levels in right kidney and histological study of hematoxylin-eosin staining (H&E) in left kidney. Results: There was a significant increase observed in Crp and BUNp, MDA levels, renal tissue wad damaged, and the FRAP reduced in the groups receiving the GM +NS compared to the sham group. A significant decrease was also observed in Crp, BUNp (p<0.001), and MDA (p<0.01), and there was a tissue damage in the GM + Centella extract group, compared to the GM + NS group. Moreover, FRAP levels increased significantly in the GM +Centella group compared to the GM+ NS group (p<0.001). Conclusion: The use of Centella asiatica extract is effective in reducing the kidney damage caused by gentamicin-induced nephrotoxicity in rats.
Types of Manuscript: Original Research | Subject: Kidney