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Abstract:   (22 Views)
Introduction: Pregabalin (PGB) is an analog of gamma-aminobutyric acid (GABA) with antinociceptive, antihyperalgesic and antiallodynic properties which frequently used in clinical pain management. Effect of PBG in neuropathic pain, incisional-inflammatory injury, post-operational pain, chronic pain and experimental pain models have already shown.
Methods: In this study, role of cholinergic and serotonergic systems in antinociceptive effect of PBG were evaluated with hot-plate and tail flick tests and also effects of drug treatment evaluated with locomotor activity cage.
Results: PGB showed antinociceptive effect on (30, 100 mg/kg) doses on hot plate and tail flick test. That antinociceptive effect of PGB abolished with ketanserin (1 mg/kg) and atropine (1 mg/kg) treatment.
Conclusion: However, there is lack of knowledge about role of nociceptive pathways underlying pregabalin mediated antinociception. Our results suggest that cholinergic and serotonergic systems have a role in antinociceptive effect of PGB which has seen in mentioned somatic pain tests.
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Types of Manuscript: Original Research | Subject: Pharmacology