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Abstract:   (837 Views)
Introduction: Chemical drugs and herbal medicine play a significant role in the management of diabetes mellitus (DM) complications. The aim of this study was to investigate the effects of Fumaria parviflora, as an herbal source, and glibenclamide, as a chemical drug, on the liver tissue of diabetic rats.
Methods: Male Wistar rats (n=32) were classified randomly into four groups (8/group), including control, diabetic (DC, induced by 50 mg/kg STZ), 250 mg/kg hydroalcoholic extract of Fumaria parviflora (DFP), and 5 mg/kg glibenclamide (DG) groups. After 21 days of treatment, liver tissues and blood samples were stored at -80°C to test lipid profile, liver enzymes, and some oxidative stress markers.
Results: In the diabetic group compared to the control group, the activities of SOD and GPx and also the serum levels of ALP were significantly decreased, while the levels of MDA, ALT, and AST enhanced. Treatment with Fumaria parviflora and glibenclamide (i.e DFP and DG groups) could manage the levels of all mentioned-parameters. Furthermore, in both treated groups (i.e DFP and DG), the rate of damages in the liver of rats reduced compared to the DC group.
Conclusion: According to the obtained results, the administration of Fumaria parviflora or glibenclamide could ameliorate the deleterious effects of DM on some investigated-parameters. As there were no difference between Fumaria parviflora and glibenclamide effects, Fumaria parviflora, could be considered as an alternative drug, at least for the diabetic complications examined in this study. However, further investigation is needed
Types of Manuscript: Original Research | Subject: Endocrinology