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Abstract:   (23 Views)
Background: Asparagus officinalis L. is a medicinal plant, which contains various natural bioactive phytochemicals with potential different pharmacological activities.
Objectives: The present study was designed to investigate the antioxidant and antinociceptive activities of the hydroalcoholic extract obtained from Asparagus roots.
Methods: The plant material was extracted using ethanol 70%, and preliminary phytochemical analyses were carried out. The in vitro antioxidant effects of the plant extract were evaluated using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals and total reducing ability compared to the butylated hydroxytoluene (BHT) as a standard control. The antinociceptive effects were also assessed using formalin and tail-flick test in male Wistar rats.
Results: The plant extract was relatively rich in flavonoids. The IC50 value for DPPH scavenging activity of the extract (1117.65 ± 14.26 µg/ml) was significantly higher than that of BHT (64.35 ± 4.09 µg/ml). The plant extract exerted a significantly lower total reducing ability compared to that of BHT. The extract exhibited a significant antinociceptive effect at the early stage of formalin test in the dose of 500 mg/kg intraperitoneally. The results of tail-flick test also demonstrated antinociceptive effects compared to control in a dose-dependent manner. However, these antinociceptive activities were not comparable with morphine as a reference agent.
Conclusion: A. officinalis roots extract demonstrated considerable antioxidant and antinociceptive activities, and it might be attributed to its flavonoids content.
Types of Manuscript: Original Research | Subject: Pharmacology