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Abstract:   (202 Views)
Introduction: Considering the limitations of conventional therapeutic methods in renal failure, researchers are paying attention to the application of Adipose-derived mesenchymal stem cells (AD-MSCs) and their protective effects against acute renal failure. This study aims to assess the therapeutic effects of AD-MSCs in gentamicin-induced renal failure in rats.
Materials and methods: In this study, 40 male Wistar rats were studied in control, Sham, gentamicin treated with and without receiving AD-MSCs. After 10 days, blood samples well collected and hemodynamic parameters, malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP) were measured in the right kidney and the left kidney underwent histologic examination.
Results: Gentamicin administration significantly increased plasma Creatinine, Blood Urine Nitrogen (P<0.001), Oxidative stress parameters and histologic damages (P<0.001); while significantly reduced FRAP (P<0.01) in the gentamicin-receiving group in comparison with the sham group. AD-MSCs treatment significantly improved renal function parameters, oxidative stress, and histologic damages in comparison with the gentamicin receiving group.
Conclusion: Intravenous injection of AD-MSCs in gentamicin-induced renal failure improved renal function, oxidative stress parameters, and histologic damages.
Types of Manuscript: Original Research | Subject: Kidney