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Abstract:   (298 Views)
OBJECTIVE: In this study the effect of zinc sulfate (ZS) supplement and eight-week continuous training (CT) and interval training (IT) on liver oxidative stress of morphine-dependent rats following withdrawal syndrome (WS) has been evaluated. MATERIALS AND METHODS: Seventy Wistar rats were randomly divided into seven groups: control rats (C), withdrawing rats (WS), withdrawing rats receiving 22.5 mg/dl ZS orally (WS+Z), withdrawing rats under CT (WS+CT), withdrawing rats under IT (WS+IT), withdrawing rats under CT and receiving 22.5 mg/dl zinc sulfate (WS+Z+CT), withdrawing rats under IT and receiving 22.5 mg/dl zinc sulfate (WS+Z +IT). Animals were addicted by 0.4 g/L morphine sulfate in 21 days. Animals in the training groups ran on a treadmill and ZS five days a week for 8 weeks. At the end of study, oxidative stress in liver tissue, and liver enzymes were measured by spectrophotometric and ELISA methods. RESULTS: ZS supplement, CT and IT lead to decrease DNA damage and malondialdehyde (MDA) in comparison with morphine group (P<0.05). Also, ZS and CT and IT significantly elevated levels in superoxide dismutase (SOD), catalase (CAT) activity, total antioxidant capacity (TAC) and thiol groups (TTG) in the liver of rats in comparison with morphine group (P<0.05). Additionally, it is observed that ZS and CT and IT made a significant reduction in AST levels in compare to the morphine group (P<0.05). CONCLUSION: These results suggest that CT and IT with ZS because of its antioxidant effects can be considered anti-addiction methods.
     
Types of Manuscript: Original Research | Subject: Others