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Abstract:   (329 Views)
Purpose: Scrophularia striata is used in traditional medicine to treat various disorders and has neuroprotective effects. There are no studies about the effects of  S. striata on cognitive functions in DZN(DZN) - exposed rats. According to the results of previous studies, vitamin E (Vit. E) can also act as a protective agent against cognitive impairments. Therefore, the present study was designed to compare the effects of Vit. E and  S. striata on DZN-induced behavioral impairments in DZN - exposed male rats .
Methods:  Neuroprotective effects of S. striata (30mg/kg/ 5 days/week for 8 weeks) and Vit. E (200 mg/kg/ 5 days/week for 8 weeks, i.p) were assessed through changes in memory,  anxiety-like behaviors , and pain threshold following DZN exposure. Open field, shuttle box, and hot plate  were used to examine anxiety-like behaviors, passive avoidance learning and memory, and pain sensitivity, respectively.
Results: Our findings indicated that exposure to DZN caused a significant decrease in memory retention and an increase in anxiety-like behaviors. S. striata and Vit.E administration compensated memory and emotional impairments induced by DZN. As well as, S. striata alone decreased reaction time against thermal stimulus  in the hot plate test. The findings of the present study also indicated that exposure to DZN significantly decreased body weight, while S. striata and Vit. E consumption restored it.
Conclusion: Results of our study indicate the protective effects of S. striata consumption like Vit. E against DZN-induced disruptions in anxiety, cognitive function, and body weight loss.
Types of Manuscript: Original Research | Subject: Learning and memory