Volume 26, Issue 1 (March 2022)                   Physiol Pharmacol 2022, 26(1): 7-19 | Back to browse issues page

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Esmailidehaj M, Kahtenaroon M, Rezvani M E, Azizian H, Ranjbar A. Enriched-asafoetida diet attenuates hyperglycemia, oxidative stress and endothelial dysfunction in type 2 diabetic rats. Physiol Pharmacol. 2022; 26 (1) :7-19
URL: http://ppj.phypha.ir/article-1-1743-en.html
Abstract:   (2135 Views)
Introduction: It has been documented that oxidative stress and inflammation are the main causes of diabetic-induced disorders. Several studies have been reported the antioxidant and antidiabetic effects of prepared asafoetida extracts, from Ferula assafoetida L. species in the Apiaceae family. The aim of the present study was to evaluate the effects of enriched-asafoetida diet (EAD) 0.5% and 2% on plasma level of glucose, hemoglobin A1C (HbA1C), insulin, lipid profile and hepatic enzymes, and vascular endothelial dysfunction induced by type 2 diabetes (T2D). Methods: Thirty-two male Wistar rats were divided into four groups: 1) control group, 2) diabetic group, 3 and 4) diabetic groups received EAD0.5% and EAD2% for 4 weeks, respectively. T2D was induced by intraperitoneal injection of nicotinamide and streptozotocin. At the end of the experiment, the plasma level of glucose, lipid profile, insulin, oxidative stress, hepatic enzymes and vascular dysfunction were evaluated. Results: Fasting blood sugar, HbA1C, oxidative stress and hepatic enzymes significantly decreased and plasma level of insulin markedly increased in the EAD0.5 compared to the diabetic group. The plasma lipid profile was improved in the EAD0.5 group. The response of thoracic aorta rings to vasodilators and vasoconstrictor substances was considerably improved in EAD0.5 than in the diabetic group. The EAD2 did not have a significant effect on diabetic induced disorders. Conclusion: The results of the present study suggest that the effects of EAD on biological disorders caused by T2D are dependent on the percentage of asafoetida in the diet.
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Types of Manuscript: Experimental research article | Subject: Blood and Immune System

1. Abu-Zaiton AS. Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pakistan J Biol Sci. 2010;13:97–100. https://dx.doi.org/10.3923/pjbs.2010.97.100 [DOI: 10.3923/pjbs.2010.97.100]
2. Al-Awadi F, Shoukry M. The lipid lowering effect of an anti-diabetic plant extract. Acta Diabetol Lat 1988; 25: 1–5. [DOI:10.1007/BF02581239]
3. Amalraj A, Gopi S. Biological activities and medicinal properties of Asafoetida: A review. Journal of Traditional and Complementary Medicine. 2017; 7: 347–359. [DOI:10.1016/j.jtcme.2016.11.004]
4. Ayoubi A, Arshami J, Valizadeh R, Mousavi Z, Mousaei A. The Effect of Asafetida Gum Extract on Blood Parameters and Histopathology of Testes in Male Wistar Rat. Iran J Anim Sci Res. 2013;4:310–5.
5. Azizian H, Rezvani ME, Esmaeilidehaj M, Bagheri SM. Anti-Obesity, Fat Lowering and Liver Steatosis Protective Effects of Ferula asafoetida Gum in Type 2 Diabetic Rats: Possible Involvement of Leptin. Iran J Diabetes Obes. 2012;4:120–6.
6. Brodsky IG. Nutritional effects of dietary protein restriction in insulin-dependent diabetes mellitus. In: Journal of Nutrition. 1998;128:2Sup. [DOI:10.1093/jn/128.2.337S]
7. Castedo E, Segovia J, Escudero C, Olmedilla B, Granado F, Blas C, et al. Ischemia-Reperfusion Injury During Experimental Heart Transplantation. Evaluation of Trimetazidine’s Cytoprotective Effect. Rev Española Cardiol (English Ed). 2005; 58: 941–950. [DOI:10.1157/13078131]
8. Chandran S, Sakthivel M, Thirumavalavan M, Thota JR, Mariappanadar V, Raman P. A facile approach to the isolation of proteins in Ferula asafoetida and their enzyme stabilizing, anti-microbial and anti-oxidant activity. Int J Biol Macromol. 2017; 102: 1211–1219. [DOI:10.1016/j.ijbiomac.2017.05.010]
9. Chukwuma CI, Matsabisa MG, Ibrahim MA, Erukainure OL, Chabalala MH, Islam MS. Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: A review. J Ethnopharmacol 2019; 235: 329–360. [DOI:10.1016/j.jep.2019.02.024]
10. Dehpour AA, Ebrahimzadeh MA, Fazel NS, Mohammad NS. Antioxidant activity of the methanol extract of Ferula assafoetida and its essential oil composition. Grasas y Aceites. 2009; 60: 405–412. [DOI:10.3989/gya.010109]
11. Esmaeili H, Sharifi M, Esmailidehaj M, Rezvani ME, Hafizibarjin Z. Vasodilatory effect of asafoetida essential oil on rat aorta rings: The role of nitric oxide, prostacyclin, and calcium channels. Phytomedicine. 2017; 36: 88–94. [DOI:10.1016/j.phymed.2017.10.002]
12. Esmailidehaj M, khaje bahabadi Z, Rezvani ME. Investigating the Effect of Oral Consumption of Tear Assafoetida on Hepatic, Renal, Cardiac, and Blood Biochemical Parameters of Rats. J Shahid Sadoughi Univ Med Sci. 2013;21:641–50.
13. Esmailidehaj M, Rezvani ME, Mosaddeghmehrjardi MH. Pretreatment with Assafoetida exerts dose-dependent dual effects on rat hearts. Pharmacogn Mag. 2014; 10: 147–153. [DOI:10.4103/0973-1296.131026]
14. Fararh KM, Atoji Y, Shimizu Y, Takewaki T. Isulinotropic properties of Nigella sativa oil in Streptozotocin plus nicotinamide diabetic hamster. Res Vet Sci 2002; 73: 279–282. [DOI:10.1016/S0034-5288(02)00108-X]
15. Giugliano D, Ceriello A, Esposito K. Glucose metabolism and hyperglycemia. In: American Journal of Clinical Nutrition. 2008;87:1. [DOI:10.1093/ajcn/87.1.217S]
16. Harris EH. Elevated liver function tests in type 2 diabetes. Clin Diabetes 2005; 23: 115–119. [DOI:10.2337/diaclin.23.3.115]
17. Hejazian S, Dashti-R M, Bagheri S. The Relaxant Effect of Seed′s Essential Oil and Oleo-gum-resin of Ferula Assa-foetida on Isolated Rat′s Ileum. Ann Med Health Sci Res. 2014;4:238. [DOI:10.4103/2141-9248.129050]
18. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res. 2001;88:e14-22. [DOI:10.1161/01.RES.88.2.e14]
19. Howlett J, Ashwell M. Glycemic response and health: Summary of a workshop. Am J Clin Nutr. 2008;87. [DOI:10.1093/ajcn/87.1.212S]
20. Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JEB. Diabetes and advanced glycoxidation end products. Diabetes Care. 2006;29:1420–32. [DOI:10.2337/dc05-2096]
21. Husna F, Suyatna FD, Arozal W, Poerwaningsih EH. Anti-Diabetic Potential of Murraya Koenigii (L) and its Antioxidant Capacity in Nicotinamide-Streptozotocin Induced Diabetic Rats. Drug Res (Stuttg). 2018;68:631–6. [DOI:10.1055/a-0620-8210]
22. Iranshahy M, Iranshahi M. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin) - A review. Journal of Ethnopharmacology. 2011; 134: 1–10. [DOI:10.1016/j.jep.2010.11.067]
23. Kasaian J, Asili J, Iranshahi M. Sulphur-containing compounds in the essential oil of Ferula alliacea roots and their mass spectral fragmentation patterns. Pharm Biol. 2016;54:2264–8. [DOI:10.3109/13880209.2016.1152279]
24. Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EGT, Swapna S, et al. Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats. Food Chem Toxicol. 2010;48:1078–84. [DOI:10.1016/j.fct.2010.01.029]
25. Kiyanmehr M, Boskabady MH, Khazdair MR, Hashemzehi M. Possible mechanisms for functional antagonistic effect of Ferula assafoetida on muscarinic receptors in tracheal smooth muscle. Malaysian J Med Sci. 2016; 23: 35–43
26. Kolluru GK, Bir SC, Kevil CG. Endothelial dysfunction and diabetes: Effects on angiogenesis, vascular remodeling, and wound healing. International Journal of Vascular Medicine. 2012. [DOI:10.1155/2012/918267]
27. Krishna Kundu N, Obayed Ullah M, Hamid K, Urmi KF, Bulbul IJ, Khan MAI, et al. Studies of lipid profile, liver function and kidney function parameters of rat plasma after chronic administration of “Sulavajrini Vatika.” Pakistan J Biol Sci. 2012;15:666–72. [DOI:10.3923/pjbs.2012.666.672]
28. Kristová V, Líšková S, Sotníková R, Vojtko R, Kurtanský A. Sulodexide improves endothelial dysfunction in streptozotocin-induced diabetes in rats. Physiol Res. 2008; 57: 491–494. [DOI:10.33549/physiolres.931506]
29. Latifi E, Mohammadpour AA, H BF, Nourani H. Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats. Biomed Pharmacother. 2019;110:197–202. [DOI:10.1016/j.biopha.2018.10.152]
30. Lee CL, Chiang LC, Cheng LH, Liaw CC, Abd El-Razek MH, Chang FR, et al. Influenza A (H1N1) antiviral and cytotoxic agents from Ferula assa-foetida. J Nat Prod. 2009;72:1568–72. [DOI:10.1021/np900158f]
31. Mahendra P, Bisht S. Ferula asafoetida : Traditional uses and pharmacological activity. Pharmacogn Rev. 2012;6:141–6. [DOI:10.4103/0973-7847.99948]
32. Mallikarjuna GU, Dhanalakshmi S, Raisuddin S, Ramesha Rao A. Chemomodulatory Influence of Ferula asafoetida on Mammary Epithelial Differentiation, Hepatic Drug Metabolizing Enzymes, Antioxidant Profiles and N-methyl-N-Nitrosourea-Induced Mammary Carcinogenesis in Rats. Breast Cancer Res Treat. 2003;81:1–10. [DOI:10.1023/A:1025448620558]
33. Mitchell JA, Ali F, Bailey L, Moreno L, Harrington LS. Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium. In: Experimental Physiology. 2008; 93: 141–147. [DOI:10.1113/expphysiol.2007.038588]
34. Nishikawa T, Edelstein D, Du XL, Yamagishi SI, Matsumura T, Kaneda Y, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000; 404: 787–790. [DOI:10.1038/35008121]
35. O’Brien RM, Granner DK. Regulation of gene expression by insulin. Physiol Rev. 1996;76:1109–61. [DOI:10.1152/physrev.1996.76.4.1109]
36. Palsamy P, Subramanian S. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed Pharmacother. 2008; 62: 598–605. [DOI:10.1016/j.biopha.2008.06.037]
37. Pari L, Sankaranarayanan C. Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats. Life Sci. 2009;85:830–4. [DOI:10.1016/j.lfs.2009.10.021]
38. Patel DK, Kumar R, Laloo D, Hemalatha S. Diabetes mellitus: An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity. Asian Pacific Journal of Tropical Biomedicine. 2012; 2: 411–420. [DOI:10.1016/S2221-1691(12)60067-7]
39. Pepato MT, Migliorini RH, Goldberg AL, Kettelhut IC. Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats. Am J Physiol - Endocrinol Metab. 1996; 271. [DOI:10.1152/ajpendo.1996.271.2.E340]
40. Sharma B, Balomajumder C, Roy P. Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem Toxicol. 2008;46:2376–83. [DOI:10.1016/j.fct.2008.03.020]
41. Shivashankara AR, Azmidah A, Haniadka R, Rai MP, Arora R, Baliga MS. Dietary agents in the prevention of alcohol-induced hepatotoxicty: Preclinical observations. Food Funct. 2012;3:101–9. [DOI:10.1039/C1FO10170F]
42. Soni KB, Rajan A, Kuttan R. Inhibition of aflatoxin-induced liver damage in ducklings by food additives. Mycotoxin Res. 1993;9:22–6. [DOI:10.1007/BF03192228]
43. Sotnikova R, Okruhlicova L, Vlkovicova J, Navarova J, Gajdacova B, Pivackova L, et al. Rosmarinic acid administration attenuates diabetes-induced vascular dysfunction of the rat aorta. J Pharm Pharmacol. 2013;65:713–23. [DOI:10.1111/jphp.12037]
44. Taylor SG, Southerton JS, Weston AH, Baker JRJ. Endothelium‐dependent effects of acetylcholine in rat aorta: a comparison with sodium nitroprusside and cromakalim. Br J Pharmacol. 1988;94:853–63. [DOI:10.1111/j.1476-5381.1988.tb11597.x 17]
45. Wold LE, Ceylan-Isik AF, Ren J. Oxidative stress and stress signaling: Menace of diabetic cardiomyopathy. Acta Pharmacol Sin. 2005;26:908–17. [DOI:10.1111/j.1745-7254.2005.00146.x]

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