Volume 28, Issue 1 (March 2024)                   Physiol Pharmacol 2024, 28(1): 10-17 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mahmoudi F, Haghighat K. The effect of pain on the neuronal activity in the hypothalamic arcuate nucleus and its consequences on the reproductive axis. Physiol Pharmacol 2024; 28 (1) : 3
URL: http://ppj.phypha.ir/article-1-2077-en.html
Abstract:   (549 Views)
Pain, an unpleasant feeling resulting from physical or psychological damage, manifests in various diseases such as migraine, fibromyalgia, rheumatoid arthritis, back pain, and neuropathy, disrupting the physiology of the body system. Prolonged pain can detrimentally affect other body tissues, leading to disorders by interfering with hormone secretion. Several studies show that pain can damage the reproductive process. Within the hypothalamus, a population of kisspeptin, neurokinin B, and dynorphin (KNDy) neurons plays an important role in regulating the reproductive axis. This study aims to investigate the effect of pain on hypothalamic neuron activity and its subsequent implications on the reproductive pathway.
Article number: 3
Full-Text [PDF 725 kb]   (101 Downloads)    
Type of Manuscript: Review | Subject: Others

References
1. Abd-Elsayed A, Jackson M, Gu S L, Fiala K, Gu J. Neuropathic pain and Kv7 voltage-gated potassium channels: the potential role of Kv7 activators in the treatment of neuropathic pain. Molecular Pain 2019;15:1-8.‌ [DOI:10.1177/1744806919864256]
2. Aguila M E R, Rebbeck T, Leaver A M, Lagopoulos J, Brennan P C, Hübscher M, et al. The association between clinical characteristics of migraine and brain GABA levels: an exploratory study. The Journal of Pain 2016; 17(10): 1058-1067. [DOI:10.1016/j.jpain.2016.06.008]
3. Alstadhaug K B. Migraine and the hypothalamus. Cephalalgia 2009;29(8):809-817.‌ [DOI:10.1111/j.1468-2982.2008.01814.x]
4. Ashina S, Bentivegna E, Martelletti P, Eikermann-Haerter K. Structural and functional brain changes in migraine. Pain and Therapy 2021; 10(1): 211-223.‌ [DOI:10.1007/s40122-021-00240-5]
5. Aykal, G, Uzun N, Derbent A U, Yeğin A. Assessment of ovarian reserve in patients with migraine. Headache Medicin 2022; 13(2):117-123. [DOI:10.48208/HeadcheMed.2022.7]
6. Ciechanowska M O, Łapot M, Kowalczyk M, Malewski T, Brytan M, Antkowiak B, et al. Does kisspeptin participate in GABA-mediated modulation of GnRH and GnRH receptor biosynthesis in the hypothalamic-pituitary unit of follicular-phase ewes?. Pharmacological Reports 2019; 71(4): 636-643.‌ [DOI:10.1016/j.pharep.2019.02.019]
7. Condorelli R A, La Vignera S, Mongioì L M, Alamo A, Calogero A E. Diabetes mellitus and infertility: different pathophysiological effects in type 1 and type 2 on sperm function. Frontiers in Endocrinology 2018; 9, 268.‌ [DOI:10.3389/fendo.2018.00268]
8. Coskun Benlidayi I. Role of inflammation in the pathogenesis and treatment of fibromyalgia. Rheumatology International 2019; 39(5): 781-791.‌ [DOI:10.1007/s00296-019-04251-6]
9. D’Andrea G, Granella F, Cataldini M, Verdelli F, Balbi T. GABA and glutamate in migraine. The journal of headache and pain 2001; 2(1): s57-s60.‌ [DOI:10.1007/s101940170011]
10. Darnall B D, Stacey B R, Chou R. Medical and psychological risks and consequences of long-term opioid therapy in women. Pain Medicine 2012; 13(9): 1181-1211.‌ [DOI:10.1111/j.1526-4637.2012.01467.x]
11. El-Tallawy S N, Nalamasu R, Salem G I, LeQuang J A K, Pergolizzi J V, & Christo PJ. Management of musculoskeletal pain: An update with emphasis on chronic musculoskeletal pain. Pain and Therapy2021; 10(1): 181-209.‌
12. Enomoto H, Iwata K, Matsumoto K, Otsuka M, Morita A, Ozawa H. Hypothalamic KNDy neuron expression in streptozotocin-induced diabetic female rats. Journal of Endocrinology 2022; 253(1): 39-51.‌ [DOI:10.1530/JOE-21-0169]
13. Finnerup NB, Kuner R, Jensen TS. Neuropathic pain: from mechanisms to treatment. Physiological Reviews2021;101(1):259-301.‌ [DOI:10.1152/physrev.00045.2019]
14. Flannagan KS, Sjaarda LA, Mumford SL,Schisterman EF. Prescription opioid use among populations of reproductive age: effects on fertility, pregnancy loss, and pregnancy complications. Epidemiologic Reviews 2020; 42(1): 117-133. [DOI:10.1093/epirev/mxaa007]
15. Goodman RL, Maltby MJ, Millar RP, Hileman SM, Nestor CC, Whited B, et al. Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes. Endocrinology2012; 153(12): 5918-5927.‌ [DOI:10.1210/en.2012-1611]
16. Harter CJ, Kavanagh GS, Smith JT. The role of kisspeptin neurons in reproduction and metabolism. Journal of Endocrinology 2018;238(3):173-183.‌ [DOI:10.1530/JOE-18-0108]
17. Hudspith MJ. Anatomy, physiology and pharmacology of pain. Anaesthesia & Intensive Care Medicine 2016; 17(9): 425-430.‌ [DOI:10.1016/j.mpaic.2016.06.003]
18. Kanasaki H, Tumurbaatar T, Oride A, Hara T, Okada H, Kyo S. Gamma-aminobutyric acid A receptor agonist, muscimol, increases KiSS-1 gene expression in hypothalamic cell models. Reproductive Medicine and Biology 2017; 16(4): 386-391.‌ [DOI:10.1002/rmb2.12061]
19. Koné MC, Kambiré NA, Ahoua Y. Impact of fibromyalgia on female infertility. Open Journal of Epidemiology 2021;11(4): 457-472.‌ [DOI:10.4236/ojepi.2021.114037]
20. Littlejohn G, Guymer E. Neurogenic inflammation in fibromyalgia. In Seminars in Immunopathology 2018; 40(3); 291-300. [DOI:10.1007/s00281-018-0672-2]
21. Martikainen IK, Hagelberg N, Jääskeläinen SK, Hietala J, Pertovaara A. Dopaminergic and serotonergic mechanisms in the modulation of pain: In vivo studies in human brain. European Journal of Pharmacology2018; 834: 337-345.‌ [DOI:10.1016/j.ejphar.2018.07.038]
22. Martins-Oliveira M, Akerman S, Holland PR, Hoffmann JR, Tavares I,Goadsby PJ. Neuroendocrine signaling modulates specific neural networks relevant to migraine. Neurobiology of disease 2017; 101: 16-26.‌ [DOI:10.1016/j.nbd.2017.01.005]
23. May A, Burstein R. Hypothalamic regulation of headache and migraine. Cephalalgia2019; 39(13): 1710-1719.‌ [DOI:10.1177/0333102419867280]
24. Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, Lai J, Ciofi P, McMullen NT, et al. Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology 2012; 153(6): 2800-2812.‌ [DOI:10.1210/en.2012-1045]
25. Moore AM, Lucas KA, Goodman RL, Coolen LM, Lehman MN. Three-dimensional imaging of KNDy neurons in the mammalian brain using optical tissue clearing and multiple-label immunocytochemistry. Scientific Reports 2018; 8(1): 1-12.‌ [DOI:10.1038/s41598-018-20563-2]
26. Nagae M, Uenoyama Y, Okamoto S, Tsuchida H, Ikegami K, Goto T, et al. Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator. Proceedings of the National Academy of Sciences 2021; 118(5): e2009156118.‌ [DOI:10.1073/pnas.2009156118]
27. Pasero C. Pathophysiology of neuropathic pain. Pain Management Nursing 2004; 5: 3-8.‌ [DOI:10.1016/j.pmn.2004.10.002]
28. Richardson E, Bedson J, Chen Y, Lacey R, Dunn KM. Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: A matched cohort study in the Clinical Practice Research Datalink. European Journal of Pain 2018; 22(9):1701-1708.‌ [DOI:10.1002/ejp.1256]
29. Ruiz-Pino F, Garcia-Galiano D, Manfredi-Lozano M, Leon S, Sánchez-Garrido MA, Roa J. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology 2015; 156(2): 576-588. [DOI:10.1210/en.2014-1026]
30. Russell IJ. Advances in fibromyalgia: possible role for central neurochemicals. The American Journal of the Medical Sciences 1998; 315(6): 377-384.‌ [DOI:10.1016/S0002-9629(15)40355-6]
31. Saedi S, Khoradmehr A, Reza JSM, Tamadon A. The role of neuropeptides and neurotransmitters on kisspeptin/kiss1r-signaling in female reproduction. Journal of Chemical Neuroanatomy 2018; 92: 71-82.‌ [DOI:10.1016/j.jchemneu.2018.07.001]
32. Salehi S, Kashfi K, Manaheji H, Haghparast A. Chemical stimulation of the lateral hypothalamus induces antiallodynic and anti-thermal hyperalgesic effects in animal model of neuropathic pain: Involvement of orexin receptors in the spinal cord. Brain Research 2020; 1732, 146674.‌ [DOI:10.1016/j.brainres.2020.146674]
33. Shin HJ, Na HS, Do SH. Magnesium and pain. Nutrients 2020; 12(8): 2184.‌ [DOI:10.3390/nu12082184]
34. Tanriverdi F, Karaca Z, Unluhizarci K, Kelestimur F. The hypothalamo–pituitary–adrenal axis in chronic fatigue syndrome and fibromyalgia syndrome. Stress 2007; 10(1):13-25.‌ [DOI:10.1080/10253890601130823]
35. Tüzün EH. Quality of life in chronic musculoskeletal pain. Best Practice & Research Clinical Rheumatology2007; 21(3): 567-579.‌ [DOI:10.1016/j.berh.2007.03.001]
36. Watanabe M, Kopruszinski CM, Moutal A, Ikegami D, Khanna R, Chen Y. Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine. Brain 2022; 145(8): 2894-2909.‌ [DOI:10.1093/brain/awac104]
37. Yang S,Chang MC. Chronic pain: structural and functional changes in brain structures and associated negative affective states. International Journal of Molecular Sciences 2019; 20(13): 3130.‌ [DOI:10.3390/ijms20133130]

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.