Volume 30, Issue 1 (March 2026)
Physiol Pharmacol 2026, 30(1): 98-109 |
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Sadegzadeh F, Sakhaie N, Banaei S, Saadati H. The impact of adolescent fluoxetine administration
on reproductive abilities and VASA gene expression. Physiol Pharmacol 2026; 30 (1) :98-109
URL: http://ppj.phypha.ir/article-1-2438-en.html
URL: http://ppj.phypha.ir/article-1-2438-en.html
Abstract: (1493 Views)
Introduction: Fluoxetine (FLX) is a commonly used antidepressant drug prescribed to treat psychiatric disturbances. According to the findings of several studies, the present work is designed to assess the influences of treating FLX during adolescence on reproductive hormone levels, ovarian and testicular tissues, and VASA gene expression in both sexes.
Methods: FLX was administered (5mg/kg/day, gavage) during adolescence (on postnatal days 21-60). After the treatment duration, blood samples were collected to measure sexual hormones. Ovarian and testicular samples were taken for histological and PCR studies.
Results: Our results indicated that FLX decreased the level of progesterone in female rats, while the level of estradiol was not changed through FLX administration. The testosterone level was decreased in FLX-treated male animals. FLX also decreased the VASA gene expression in both sexes, but this effect was significant in female rats. Besides, our findings showed the potency of FLX in inducing tissue damage, degeneration of follicles, and hypospermatogenesis.
Conclusion: Therefore, treatment with FLX during adolescence leads to a decrease in reproductive activities during adolescence.
Methods: FLX was administered (5mg/kg/day, gavage) during adolescence (on postnatal days 21-60). After the treatment duration, blood samples were collected to measure sexual hormones. Ovarian and testicular samples were taken for histological and PCR studies.
Results: Our results indicated that FLX decreased the level of progesterone in female rats, while the level of estradiol was not changed through FLX administration. The testosterone level was decreased in FLX-treated male animals. FLX also decreased the VASA gene expression in both sexes, but this effect was significant in female rats. Besides, our findings showed the potency of FLX in inducing tissue damage, degeneration of follicles, and hypospermatogenesis.
Conclusion: Therefore, treatment with FLX during adolescence leads to a decrease in reproductive activities during adolescence.
Type of Manuscript: Experimental research article |
Subject:
Neurophysiology/Pharmacology
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