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Shahrokh Khoshsirat 
, Narges Bazgir , Haideh Mosleh , Simin Raissi , Elanaz Amanzadeh jajin , Somayeh Niknazar
, Narges Bazgir , Haideh Mosleh , Simin Raissi , Elanaz Amanzadeh jajin , Somayeh Niknazar
Abstract: (18 Views)
Introduction: Many individuals experience age-related hearing loss (ARHL), yet it frequently goes unnoticed. Its prevalence increases twofold with every ten years of age. Epigenetics is linked to heritable modifications in gene activity that are not caused by alterations in DNA sequence. Epigenetic changes are caused by environmental exposure and genetic variation and can help to understand why a person with good health may develop hearing disorders. In this review, our goal is to assess the variety of DNA methylation in individuals with ARHL.
Methods: We conducted a systematic review of studies that report changes in DNA methylation among patients with presbycusis. The study used the PECO framework to establish the eligibility criteria for patients with ARHL. Search was performed on Embase, PubMed, Scopus, Google Scholar, and ScienceDirect. Furthermore, a functional annotation enrichment analysis was performed on the genes that were variably methylated in hearing disorders.
Results: A total of seven studies evaluating about 700 individuals with ARHL were reviewed. Various genes including P2RX2, KCNQ5, SOCS3, ERBB3, TCF25, POLE, ESPN, TNFRSF25, FGFR1, CDH23, SLC26A4, MEF2D, LCK, and GBX2 were differentially methylated. After conducting enrichment analysis and generating important gene modules in Cytoscape by Molecular Complex Detection (MCODE) plugin, it was revealed that ERBB3, P2RX2, and FGFR1 were involved in calcium signaling pathway. Many differentially methylated genes were discovered in ARHL individuals.
Conclusion: This review demonstrated that DNA methylation could cause development of ARHL. Changes in gene methylation can disrupt the calcium signaling pathway, potentially leading to presbycusis.
Methods: We conducted a systematic review of studies that report changes in DNA methylation among patients with presbycusis. The study used the PECO framework to establish the eligibility criteria for patients with ARHL. Search was performed on Embase, PubMed, Scopus, Google Scholar, and ScienceDirect. Furthermore, a functional annotation enrichment analysis was performed on the genes that were variably methylated in hearing disorders.
Results: A total of seven studies evaluating about 700 individuals with ARHL were reviewed. Various genes including P2RX2, KCNQ5, SOCS3, ERBB3, TCF25, POLE, ESPN, TNFRSF25, FGFR1, CDH23, SLC26A4, MEF2D, LCK, and GBX2 were differentially methylated. After conducting enrichment analysis and generating important gene modules in Cytoscape by Molecular Complex Detection (MCODE) plugin, it was revealed that ERBB3, P2RX2, and FGFR1 were involved in calcium signaling pathway. Many differentially methylated genes were discovered in ARHL individuals.
Conclusion: This review demonstrated that DNA methylation could cause development of ARHL. Changes in gene methylation can disrupt the calcium signaling pathway, potentially leading to presbycusis.
Type of Manuscript: Review |
Subject:
Clinical Physiology/Pharmacology
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