Volume 10, Issue 4 (Winter 2007)
Physiol Pharmacol 2007, 10(4): 303-311 |
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Khori V, Nayebpour M. Effect of Artemisia absinthium on electrophysiological properties of isolated heart of rats . Physiol Pharmacol 2007; 10 (4) :303-311
URL: http://ppj.phypha.ir/article-1-289-en.html
URL: http://ppj.phypha.ir/article-1-289-en.html
Abstract: (16500 Views)
Introduction: Treatment of supraventricular arrhythmia includes wide range of medical
interventions. Herbal remedies are suitable alternatives for synthetic drugs due to their
availability, minimal side effects and lower price. Pharmacological studies and traditional
medical literature point to the cardiovascular effects of the Artemisia absinthium L. from
Compositae family of plants.
Methods: In the present study we used Langendorff model of isolated heart of rats as an
experimental model to determine the effect of various concentrations of methanolic extract
of A. absinthium (3×10 -11 %W/V to 4× 10 -8 %W/V) on electrophysiological properties of
isolated hearts.
Results: Our results showed depressant effect of A. absinthium extract on Wenchebach
Cycle Length (WBCL), AV Conduction Time (AVCT), Effective and Functional Refractory
Periods (ERP & FRP) of the isolated heart.
Conclusion: The results indicated potential antiarrhythmic effect of A. absinthium extract
in treating supraventricular tachyarrhythmia.
Type of Manuscript: Experimental research article |
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