Volume 10, Issue 4 (Winter 2007)
Physiol Pharmacol 2007, 10(4): 243-249 |
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Gharibnaseri M K, Mard S A. Gastroprotective effect of Alhagi camelorum on experimental gastric ulcer in rats . Physiol Pharmacol 2007; 10 (4) :243-249
URL: http://ppj.phypha.ir/article-1-295-en.html
URL: http://ppj.phypha.ir/article-1-295-en.html
Abstract: (15311 Views)
Introduction: Alhagi camelorum belongs to the Leguminosae family is used in Iranian
folk medicine to treat some gastric diseases. The present study was undertaken to evaluate
the Alhagi camelorum aqueous extract for anti-ulcer activity in rats.
Methods: Male Wistar rats were pretreated with the A. camelorum aqueous extract (150,
300 or 450 mg/kg of B.W., P.O.) before induction of gastric ulcer by water immersion
restraint-stress at 20-22 °C (5 h) or before induction of the ulcer by ethanol 100% (1
ml/200g of B.W., P.O.). Negative control animals received saline (0.5 ml/100 g of B.W.).
Positive control animals received ranitidine (60 mg/kg, P.O.).
Results: The A. camelorum aqueous extract (ACE) protected rats against water
immersion restraint-stress and ethanol-induced ulcers in a dose-dependent manner. In water
immersion restraint induced ulcerated rat, the ACE increased pH and reduced gastric acid
content. ACE did not show any signs of toxicity and mortality up to10 g/kg, P.O. in mice.
Conclusion: The results suggest that A. camelorum aqueous extract can exert significant
mucosal protection and antisecretory effects on gastric mucosa in rats.
Type of Manuscript: Experimental research article |
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