Volume 6, Issue 1 (Spring and Summer 2002)                   Physiol Pharmacol 2002, 6(1): 0-0 | Back to browse issues page

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Salami M, Fathollahi Y. Involvement of voltage-dependent calcium channels in synaptic plasticity of the rat visual cortex. Physiol Pharmacol 2002; 6 (1)
URL: http://ppj.phypha.ir/article-1-401-en.html
Involvement of voltage-dependent calcium channels in synaptic plasticity of the rat visual cortex
Mahmood Salami , Yagoob Fathollahi
Abstract:   (15226 Views)
In this study, involvement ofvoltage-dependent calcium channels in LTP of responses of rat visual cortex slices was analyzed. Field potentials including EPSP1 and EPSP2 from layers II/III were recorded through stimulation of layer IV. Whereas nifedipine, a L-type calcium channel blocker (L-VDCC), did not considerably affect the LTP of responses, but Ni2+, a relatively selective blocker of T-type calcium channels (T-VDCC) decreased potentiation of EPSP1 and partly blocked that of EPSP2. The effect of visual experience on the function of channels was also evaluated. The results showed that T-VDCCs mediate a transient augmentation of EPSP1, while contribute to a stable LTP of EPSP2. Whereas sensory experience influences the occurrence of LTP in field potentials, it seems to be ineffective on the role of calcium channels in synaptic plasticity. It is concluded that the T-VDCCs alone by allowing calcium influx into neurons or by sharing NMDA receptors are involved in the synaptic plasticity.
Keywords: Calcium channels; LTP; Synaptic plasticity; Visual cortex
     
Type of Manuscript: Experimental research article |
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