Volume 13, Issue 4 (Winter 2010)                   Physiol Pharmacol 2010, 13(4): 362-370 | Back to browse issues page

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Saadat H, Ziai S A, Nasri S, Sakenshaft M, Ansarian A. Study of the correlation between ACE gene polymorphism and coronary artery disease. Physiol Pharmacol. 2010; 13 (4) :362-370
URL: http://ppj.phypha.ir/article-1-570-en.html
Abstract:   (15587 Views)
Introduction: Angiotensin converting enzyme (ACE) is an exopeptidase that converts Angiotensin I to Angiotensin II. Angiotensin II is a potent vasoconstrictor and releases aldosterone, and have a critical role in hypertension. In this study, ACE insertion / deletion (I/D) polymorphism and ACE activity was determined in patients with coronary artery disease (CAD) and normal subjects. The correlation of these parameters with important CAD risk factors were also evaluated. Methods: 204 subjects were assigned to patients and normal groups based on their angiography results. Serum ACE activities were assayed by HPLC and I/D polymorphism were analyzed by PCR method. Important risk factors such as diabetes mellitus, hypertension, lipid profiles, ejection fraction, smoking and opium consumption were also recorded. Results: CAD was higher in DD genotype subjects (OR= 2.45 CI= 1.05-5.73), and ACE activity was about twice in DD compared to II genotypes. ACE activity was higher in hypertensives and diabetics in CAD group (p<0.001), but in the normal group it did not have any correlation with these risk factors. The rate of opium use was higher in ID and DD subjects. Conclusion: DD genotype is a risk factor for CAD and ACE activity is higher in this genotype. However, there is not any correlation between ACE activity and CAD.
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Types of Manuscript: Original Research | Subject: Cardivascular system

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