Volume 14, Issue 1 (Spring 2010)
Physiol Pharmacol 2010, 14(1): 34-40 |
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Garavand S, Keramati K, Zendehdel M, Jadidoleslami M, Garavand S. Effect of intracerebroventricular injection of flunixin meglumine on PTZ-induced seizures in male rats. Physiol Pharmacol 2010; 14 (1) :34-40
URL: http://ppj.phypha.ir/article-1-576-en.html
URL: http://ppj.phypha.ir/article-1-576-en.html
Abstract: (14060 Views)
Introduction: Flunixin Meglumine (FM) is a nonsteroidal antiinflammatory drug (NSAID) and nonselective
cyclooxygenase (COX) inhibitor. Since it has been suggested that COX enzyme plays a role in seizure, this research is
performed to assess the therapeutic effects that this compound might have in seizures induced by PTZ.
Methods: In this research, male wistar rats (200 ± 20 g) were given intracerebroventricular injections of saline or
FM (12.5 μg, 25 μg and 50 μg) in a 1 μl volume, before intraperitoneal administration of PTZ (80 mg/kg) for induction
of seizure. Then, seizure score and times of onset for every stage of seizure were recorded during 20 minutes after PTZ
administration. The data were analyzed by one-way analysis of variance (ANOVA).
Results: injection of 25 and 50 μg of FM significantly increased times of onset of every seizure stage compared to
the control group. The group that received 50 μg of FM did not show stage 5. On the other hand, 12.5 μg FM group did
not show any significant difference with the control group.
Conclusion: We conclude that FM has dose dependent anticonvulsive properties.
Type of Manuscript: Experimental research article |
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