Abstract: (15558 Views)
Introduction: Gama amino butyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian
nervous system. The concentration of GABA and the number of GABA cell secretion decrease in diabetic patient and
experimental diabetes model. The reported effects of GABA activation on insulin secretion from beta cells have been
controversial. In this study we investigated if GABA administration in animal diabetes model can change insulin and
glucagon secretion and improve some diabetic symptoms.
Methods: Twenty fourth-week old NOD mi(Non obese diabetic mice) ce were used. Two months after diabetic
induction animals were divided into the two groups. One group received 200 μmol of GABA and the other group
received phosphate buffer solution (PBS) for one month.
Results: GABA administration could significantly decrease plasma glucose and glucagon level, water consumption
and urine volume and body fat distribution in the mesenteric bed and abdominal wall. It also could increase plasma Cpeptide
level and it has not effect on food intake.
Conclusion: NOD mice is very good genetically model for type one diabetes and GABA administration in this mice
could treatment some of diabetic symptom. It seems may be we could use of GABA for treatment of diabetic symptom
in future.
Keywords: Type one diabetes, GABA, C-peptide, Glocagon, glucose, NOD mice.