Volume 14, Issue 3 (Fall 2010)
Physiol Pharmacol 2010, 14(3): 302-317 |
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Mohammadi-Motlagh H, Mansouri K, Mostafaie A. Plants as useful agents for angiogenesis and tumor growth prevention . Physiol Pharmacol 2010; 14 (3) :302-317
URL: http://ppj.phypha.ir/article-1-592-en.html
URL: http://ppj.phypha.ir/article-1-592-en.html
Abstract: (14740 Views)
Introduction: Angiogenesis, the process of new blood vessel formation from pre-existing vessels, has important
physiological roles in embryonic development, female reproduction cycle, and wound healing. It is also crucial for
pathological processes in several diseases especially tumor growth and metastasis. Thereby, inhibition of angiogenesis
as an addition to the conventional therapies such as chemotherapy and radiotherapy has attracted the attention of
scientists.
Results: Different studies have shown that botanical derivatives specifically antagonize new vessel formation in
tumors without significant toxicity to normal tissues and without major adverse reactions. Furthermore, many studies
have revealed that the active ingredients of these natural products inhibit tumor cell proliferation through interference
with other physiological pathways such as intracellular signaling pathways. A number of studies have also
demonstrated that many traditional foods especially plant derived foods have preventive potential against around one
third of cancers. Therefore, plant rich diet can inhibit the progression of many chronic diseases such as malignant solid
tumors which are related to angiogenesis.
Type of Manuscript: Experimental research article |
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