Volume 14, Issue 4 (Winter 2011)
Physiol Pharmacol 2011, 14(4): 338-348 |
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Kourosh Arami M, Semnanian S, Javan M, Hajizadeh S, Sarihi A. Postnatal developmental alterations in the locus coeruleus neuronal fast excitatory postsynaptic currents mediated by ionotropic glutamate receptors of rat. Physiol Pharmacol 2011; 14 (4) :338-348
URL: http://ppj.phypha.ir/article-1-632-en.html
URL: http://ppj.phypha.ir/article-1-632-en.html
Abstract: (12616 Views)
Introduction: In the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal
development of excitatory postsynaptic currents in locus coeruleus neurons.
Methods: In this study, AMPA and NMDA receptor-mediated spontaneous synaptic currents in the neurons of locus
coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks.
Results: The frequency and amplitude of NMDA sEPSCs and the frequency of AMPA sEPSCs were increased in
the second and third postnatal weeks compared with these parameters recorded in the first postnatal week. However, the
ratio of the AMPA to NMDA current frequency and amplitude was constant until the 3rd postnatal week.
Conclusion: These findings suggest that a vast majority of nascent glutamatergic synapses express both functional
AMPA and NMDA receptors in the postnatal locus coeruleus, so that AMPA/NMDA sEPSCs remained constant during
this period.
Type of Manuscript: Experimental research article |
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