Volume 17, Issue 1 (Spring 2013)
Physiol Pharmacol 2013, 17(1): 60-71 |
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Khori V, Alizadeh A M, Moheimani H, Shakiba D, Soroosh Aminolsharieh Najafi S, Alizadeh S, et al . New manifestations of electrophysiological remodeling of heart during experimental model of atrial fibrillation in cirrhotic rat isolated heart. Physiol Pharmacol 2013; 17 (1) :60-71
URL: http://ppj.phypha.ir/article-1-884-en.html
URL: http://ppj.phypha.ir/article-1-884-en.html
Vahid Khori 
, Ali mohammad Alizadeh , Hamidreza Moheimani , Delaram Shakiba , Soroosh Soroosh Aminolsharieh Najafi , Shahryar Alizadeh , Taghi Amiriyani , Ardeshir Banikarimi , Mahdi Zahedi , Mohamad hadi Molseghi , Ahmadreza Dehpour
, Ali mohammad Alizadeh , Hamidreza Moheimani , Delaram Shakiba , Soroosh Soroosh Aminolsharieh Najafi , Shahryar Alizadeh , Taghi Amiriyani , Ardeshir Banikarimi , Mahdi Zahedi , Mohamad hadi Molseghi , Ahmadreza Dehpour
Abstract: (11020 Views)
Introduction: The present study is aimed to evaluate electrophysiological remodeling of atrioventricular (AV) node
and ventricular conduction during experimental atrial fibrillation (AF) model in isolated heart of cirrhotic rats.
Methods: Cirrhosis-induced electrophysiological remodeling was evaluated in 24 isolated retrogradely perfused rat
hearts in 2 groups (control and cirrhotic). Cirrhosis was induced after 6 weeks of common bile duct ligation in rats.
Extracellular filed potential was recorded from upper atrium and right ventricle. The conduction time, refractoriness and
frequency-dependent properties of AV node were characterized by specific stimulation protocols. Experimental AF
was simulated by high-rate atrial pacing with random coupling intervals (range 75–125 ms).
Results: Nodal conduction time and ventricular responsiveness were significantly increased in the cirrhotic rats
compared to the control (95.8 ± 4.2 ms vs. 78.8 ± 3.3 ms) (P< 0.05). Nodal protective function during AF was
potentiated with increased R-R interval, concealed beats, ventricular refractoriness and zone of concealment in the
cirrhotic group. Cirrhosis evoked rate–dependent ventricular conduction time shortening with different patterns during
arrhythmia.
Conclusion: Cirrhosis-induced electrophysiological remodeling was shown by increased AV nodal conduction and
shortened ventricular conduction. This electrophysiological remodeling may be considered as a new manifestation of
cirrhotic cardiomyopathy in the heart, which can change ventricular rhythm during arrhythmia.
Type of Manuscript: Experimental research article |
Subject:
Cardiovascular Physiology/Pharmacology
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