Volume 17, Issue 2 (Summer 2013)
Physiol Pharmacol 2013, 17(2): 194-203 |
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Rezaie A, Roozbeh M, Goorani nejad S, Najaf Zadeh Varzi H, Fatemi Tabatabaei S R, Pourmahdi-broojeni M. Effects of Tribulus Terrestris extract and Vitamin C on changes induced by cyclophosphamide in the rat ovary. Physiol Pharmacol 2013; 17 (2) :194-203
URL: http://ppj.phypha.ir/article-1-892-en.html
URL: http://ppj.phypha.ir/article-1-892-en.html
Annahita Rezaie 
, Meysam Roozbeh , Saad Goorani nejad , Hossein Najaf Zadeh Varzi , Seyed Reza Fatemi Tabatabaei , Mahdi Pourmahdi-broojeni
, Meysam Roozbeh , Saad Goorani nejad , Hossein Najaf Zadeh Varzi , Seyed Reza Fatemi Tabatabaei , Mahdi Pourmahdi-broojeni
Abstract: (11276 Views)
Introduction: Cyclophosphamide (CYP) is an alkylating agent, which is used in different diseases. It has several
important side effects on ovaries. Tribulus terrestris extract (TTE) has different steroidal saponins and has been used
for a long time as an aphrodisiac. The aim of this study was to evaluate the protective effects of TTE on the toxicity of
CYP in the ovary of rats.
Methods: Forty-eight female rats were divided into 6 groups. First group received only normal saline. Group 2, 3
and 5 received CYP (30 mg/kg, 2 times/week for 7 weeks). Groups 3 and 4 received TTE (10 mg/kg, 2 times/week for
10 weeks) and groups 5 and 6 received vitamin C (80 mg/kg, 2 times/week for 7 weeks). At the end of study, blood was
collected and the rats were sacrificed. Ovaries were dissected for the histopathological study. Serum levels of estrogen
were measured.
Results: Histopathological examination revealed significant decrease in the number of follicles in group 2. Estrogen
was significantly decreased by CYP in comparison with other groups. Number of follicles in group 3 and 5 were
increased. Estrogen levels were also increased.
Conclusion: These findings indicated that TTE similar to Vitamin C may improve the side effects of CYP toxicity
in the ovary of rats.
Type of Manuscript: Experimental research article |
Subject:
Pharmacokinetics/Dynamics
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