Rabiei Z, Rafieian M. Effects of Zizyphus jujuba Extract on Motor Coordination Impairment Induced by Bilateral Electric Lesions of the Nucleus Basalis of Meynert in Rat. Physiol Pharmacol 2014; 17 (4) :469-477
URL:
http://ppj.phypha.ir/article-1-941-en.html
Abstract: (9805 Views)
Introduction: Alzheimer’s Disease (AD) is a chronic neurological disorder characterized by memory impairment,
cognitive dysfunction, behavioral disturbances, and deficits in activities of daily living. AD has been found to be
associated with a cholinergic deficit in the post-mortem brain characterized by a significant decrease in acetylcholine
amount and loss of cholinergic neurons of the nucleus basalis of Meynert (NBM). This study investigated the effect of
Zizyphus jujuba (ZJ) extract on motor activity in NBM-lesioned rat model of AD and intact rats.
Methods: In this study, 49 wistar rats were divided into 7 groups. Rats received bilateral electrolytic lesions of the
NBM. The control and sham group received distilled water while NBM-lesioned groups received ZJ extract via gastric
gavage for 20 days. Intact rats received ZJ extract for 20 days without any surgery. The motor activity assessed with
rota-rod apparatus. Data were compared using one way ANOVA followed by LSD post test.
Results: ZJ extract for 20 days improved motor activity in NBM-lesioned rats and intact rats that received extract at
the dose of 1000 mg/kg.
Conclusion: Results suggest that ZJ extract can improve the motor coordination both in NBM-lesioned rats and in
intact rats.