Volume 18, Issue 3 (Fall 2014)
Physiol Pharmacol 2014, 18(3): 327-336 |
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Moaiedfard Z, Eshagh Harooni H, Moazedi A A, Parham G A, Niknejad S. Effect of intrahippocampal L-NAME injection on passive avoidance memory in adult male rats exposed to restraint stress. Physiol Pharmacol 2014; 18 (3) :327-336
URL: http://ppj.phypha.ir/article-1-973-en.html
URL: http://ppj.phypha.ir/article-1-973-en.html
Abstract: (7270 Views)
Introduction: Nitric oxide is an important messenger in hippocampal region which is affected in learning and
memory processes and hippocampal responses to stress. In this study, we investigated the effect of L-NAME on passive
avoidance memory in adult male rats exposed to restraint-stress.
Methods: For this purpose, male Wistar rats were bilaterally implanted with cannulas aimed at the CA1 region of
the hippocampus. Thirty min after intrahippocampl injections of saline (alone) or L-NAME (20, 40 and
80μg/0.5μl/side) animals were immobilized in restrainer for 2 h/day for 7 days (7 days after surgery), and then were
tested for step-through latency and the time-spent in dark chamber in inhibitory avoidance task.
Results: Our findings showed that intrahippocampal injection of L-NAME (80 μg/0.5 μl/side) significantly
increased the step-through latency and decreased the time spent in the dark chamber in comparison with the control
group.
Conclusion: Since the inhibition of NO synthesis resulted in memory and learning improvements in rats exposed to
restraint-stress, NO might be involved in stress related learning and memory deficits.
Type of Manuscript: Experimental research article |
Subject:
Neurophysiology/Pharmacology
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