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Abstract:   (86 Views)
Introduction: Given that pelargonidin is an anthocyanin that exhibits neuroprotective effects and Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-beta (Aβ) and cognitive dysfunction subsequently, herein, we examined the effects of pelargonidin on amyloid β (Aβ) -induced long- term potentiation deficits in rats. Methods: AD was induced using intrahippocampal injections of the Aβ in the adult Wistar male rats.  The rats received single intraperitoneal injections of pelargonidin (3 mg/kg). Long-term potentiation (LTP) in the perforant path-DG synapses was assessed electrophysiologically by measuring the field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude. Results: Our results showed that Aβ significantly decreased fEPSP slope and SP amplitude in comparison with the control and sham groups (p<0.05), whereas pelargonidin increased these parameters in comparison to the Aβ group (p<0.001). Conclusion: It is probably that pelargonidin could improve Aβ-induced cognition deficit in rats.
Types of Manuscript: Original Research | Subject: Neurodegeneretive diseases